16 apr. 2015 — Bioteknikbolaget Active Biotech och samarbetspartnern Ipsen avbryter alla studier av tasquinimod för behandling av prostatacancer.

In April 2011, Ipsen and Active Biotech entered into a broad partnership for the co-development of tasquinimod for the treatment of cancer. Active Biotech granted Ipsen exclusive rights to commercialize tasquinimod worldwide, except in North and South America and Japan where Active Biotech retained all commercial and marketing rights.

tasquinimod Paris (France) and Lund (Sweden), 3 October 2012 – Ipsen (Euronext: IPN; ADR: IPSEY) and Active Biotech (NASDAQ OMX NORDIC: ACTI) today announced the initiation of a new phase II proof of concept clinical trial, evaluating the activity of tasquinimod in advanced metastatic castrate resistant prostate cancer patients. Ipsen presents preliminary results of exploratory proof-of-concept study with tasquinimod in four advanced tumor types at the ESMO 2014 Congress Clinical data not supporting further development of tasquinimod in monotherapy in heavily pretreated patients … Ipsen Presents Preliminary Results of Exploratory Proof-of-Concept Study with Tasquinimod in Four Advanced Tumor Types at the ESMO 2014 Congress (2)IPSEN Oncology and Biomarkers, Les Ulis, France. (3)Active Biotech AB, Lund, Sweden. BACKGROUND: Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that inhibits occurrence of experimental metastasis and delays disease progression of … Tasquinimod modulates tumor-inﬁltrating myeloid cells and improves the antitumor immune response to PD-L1 blockade in Anne-Laure Bauchet, Pascale Plas, Amath Thiongane, Florence Meyer-Losic, and Fabien Schmidlin IPSEN Innovation, Global Drug Discovery department, Les Ulis, France ARTICLE HISTORY Received 17 November 2015 Revised 6 January 2015-12-15 2015-04-16 2015-12-01 Tasquinimod treatment also affected expression of factors involved in the pre‐metastatic niche in the bone microenvironment (Lox , Cdh2 , Cdh11 , and Cxcl12 ). In addition, tasquinimod treatment caused a decreased osteogenic response indicated by decreased expression of Ocn , Runx2 , and Col1a2 and increased expression of osteoclast stimulating CSF2. <0> Ipsen initiates a phase II “Switch maintenance” trial in metastatic castrate-resistant prostate cancer with tasquinimod RegulatoryNews: 2012-10-03 In 2011, Active Biotech and Ipsen entered into a broad partnership for the co-development and commercialization of tasquinimod. Under the terms of the agreement, Active Biotech has granted Ipsen exclusive rights to commercialize tasquinimod worldwide, except for North and South America and Japan, where Active Biotech has retained all commercial and marketing rights.

Here we investigated whether pharmacological inhibition of S100A9 with tasquinimod inhibits MM progression. 2015-04-16 Active Biotech and Ipsen Announce Their Decision to Discontinue the Development of tasquinimod in Prostate Cancer April 16, 2015 01:00 AM Eastern Daylight Time LUND, Sweden & PARIS--( BUSINESS Active Biotech receives tasquinimod milestone payment from Ipsen for 10TASQ10 study. By: Active Biotech via GlobeNewswire News Releases. October 09, 2013 at 01:36 AM EDT. LUND, Sweden and PARIS, Oct. 9, 2013 (GLOBE NEWSWIRE) -- Active Biotech (NASDAQ OMX NORDIC: ACTI) and Ipsen 2013-10-09 PARIS, France—Active Biotech AB and Ipsen have entered intoa broad partnership to co-develop and commercialize Active Biotech'sinvestigational compound Tasquinimod (TASQ). A global Phase III trial of TASQin men with metastatic castrate-resistant prostate cancer (CRPC) was recentlyinitiated by Active Biotech, and patient recruitment has begun.

16 apr. 2015 — Bioteknikbolaget Active Biotech och samarbetspartnern Ipsen avbryter alla studier av tasquinimod för behandling av prostatacancer.

Tasquinimod binds to the regulatory Apr 15, 2015 Active Biotech and Ipsen announce their decision to discontinue the development of tasquinimod in prostate cancer. This article or press Global Marketing Director tasquinimod. Ipsen.

2015-12-15

About tasquinimod Tasquinimod is a novel small molecule that targets the tumor microenvironment by binding to S100A9 and modulating regulatory myeloid cell functions, exerting immunomodulatory, anti-angiogenic and anti tasquinimod Paris (France) and Lund (Sweden), 3 October 2012 – Ipsen (Euronext: IPN; ADR: IPSEY) and Active Biotech (NASDAQ OMX NORDIC: ACTI) today announced the initiation of a new phase II proof of concept clinical trial, evaluating the activity of tasquinimod in advanced metastatic castrate resistant prostate cancer patients. Ipsen presents preliminary results of exploratory proof-of-concept study with tasquinimod in four advanced tumor types at the ESMO 2014 Congress Clinical data not supporting further development of tasquinimod in monotherapy in heavily pretreated patients with advanced ovarian, renal cell and gastric carcinomas Ipsen Presents Preliminary Results of Exploratory Proof-of-Concept Study with Tasquinimod in Four Advanced Tumor Types at the ESMO 2014 Congress Tasquinimod (ABR-215050, CID 54682876) is an experimental drug currently being investigated for the treatment of solid tumors. Tasquinimod has been mostly studied in prostate cancer , but its mechanism of action suggests that it could be used to treat other cancers. (2)IPSEN Oncology and Biomarkers, Les Ulis, France. (3)Active Biotech AB, Lund, Sweden. BACKGROUND: Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that inhibits occurrence of experimental metastasis and delays disease progression of castration resistant prostate cancer in humans.

BACKGROUND: Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that inhibits occurrence of experimental metastasis and delays disease progression of castration resistant prostate cancer in humans. Ipsen strengthens its business in urology-oncology with the acquisition of the rights to HEAVY ® (a drug aimed at improving bladder cancer detection) and the establishment of two significant partnerships with: Active Biotech for the co-comelopment and commercialization of tasquinimod (a molecule for the treatment of metastatic and castration-resistant prostate cancers), and Institut Gustave Ipsen and Active Biotech today announced the initiation of a new phase II proof of concept clinical trial, evaluating the activity of tasquinimod in advanced metastatic castrate resistant prostate Ipsen (Euronext: IPN; ADR: IPSEY) har idag på den vetenskapliga konferensen “2012 ASCO Annual Meeting” som hålls i Chicago (USA) presenterat överlevnadsdata (OS) från tasquinimod Överlevnadsdata från fas II presenterade på 2012 ASCO Annual Meeting Lund och Paris (Frankrike) den 4 juni 2012, Active Biotech (NASDAQ OMX NORDIC: ACTI) och Ipsen (Euronext: IPN; ADR: IPSEY Active Biotech receives tasquinimod milestone payment from Ipsen. This announcement is distributed by Thomson Reuters on behalf of Thomson Reuters clients.
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Today at 08:00 am CDT (3:00 pm CET) Dr. … Background: Tasquinimod is a small molecule with immunomodulatory, anti-angiogenic, and anti-metastatic properties that targets the tumor microenvironment. This study aimed to obtain a clinical proof of concept that tasquinimod was active and tolerable in patients with advanced solid tumors. 2012-06-04 2012-06-04 Active Biotech and Ipsen Report Tasquinimod (TASQ) Phase II Long Term Safety Data at the 27 th European Association of Urology (EAU) Congress February 24, 2012 02:30 AM Eastern Standard Time Potential $285M: Ipsen and Active Biotech in TASQ Deal. // Bioworld Week;4/25/2011, Vol. 19 Issue 17, p3 . The article reports that Active Biotech AB could gain 35.6 million U.S. dollars and additional 249.4 million U.S. dollars from its partnering agreement with Ipsen SA on its cancer drug tasquinimod (TASQ).

09:54 Bakslag sänker Active Biotech.
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Study Of Tasquinimod In Asian Chemo-Naïve Patients With Metastatic Castrate-Resistant Prostate Cancer (TasQ003) Ipsen: More Information. Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information.

2015 — torsdagsmorgonen efter att bolaget och partnern Ipsen har beslutat att avsluta utvecklingen av tasquinimod för behandling av prostatacancer. 1 juni 2015 — Active Biotech meddelade i mitten av april att man, tillsammans med läkemedelsbolaget Ipsen, avbröt alla studier av tasquinimod, som Efter nya studiedata avbryter Active Biotech och Ipsen alla studier av tasquinimod som behandling av prostatacancer. Projektet med tasquinimod är i en registreringsgrundande klinisk fas III- studie (10TASQ10) laquinimod med Teva och tasquinimod med Ipsen;. □ avyttring av tasquinimod som bland annat visade ingen förlängd överlevnad för patienter med prostatacancer lades projektet ned och samarbetet med Ipsen avvecklades. Bakom kursslakten ligger att Active Biotech och partnern Ipsen beslutat att avsluta utvecklingen av tasquinimod för behandling av prostatacancer. 1 juni 2015 — Ipsen avbröt alla studier av läkemedelskandidaten tasquinimod som visade att totalöverlevnaden vid behandling med tasquinimod jämfört 16 apr. 2015 — Bioteknikbolaget Active Biotech och samarbetspartnern Ipsen avbryter alla studier av tasquinimod för behandling av prostatacancer.